Monday, February 25, 2013

Wolf Snake Rescued by the Kids


Our kids John Rommel, and Saranya Carr were at their friend Fara's house one night recently when someone outside started screaming "snake!" On rushing out the kids found a group of terrified people including Fara's mom having hysterics over a snake. The discussion was already on as to how they could best set it on fire and who was going to whack it!

After calming them down a bit, with the help of a backpack, the offender was coaxed into hiding in the bag by Vasanth, Saran, Rommel, and Manuraj, the bag zipped up, and our friend, as yet unidentified, was brought home.

We took a look under good light and it turned out to be a 2 foot wolf snake.

The Indian wolf snake (Lycodon aulicus) is a very pretty and nonvenomous snake that's actually fairly  common even in towns and cities. Human towns tend to have high populations of mice and rats, and are therefore attractive to snakes such as the wolf and trinket snake.

We did try to get the forest department to come and pick the wolf up, as that's the proper procedure, but they declined, so Rommel and his friend Dinu took our pretty wolf out to a nearby mountain  range where there's a good stretch of reserve forest and one very happy snake was released to the wild.





If you aren't too sure about identifying snakes and deciding whether they might be venomous, check out our earlier post to help you identify India's venomous Big 4  and to give you a few tips on dealing with snake bite - just in case!


Sunday, February 24, 2013

Goodbye CREAM Hello Derek & the Dominos

Cream's farewell concert, Royal Albert Hall (London) 1968. A legendary group, they started hard rock & heavy metal, and then broke up...



A little over 60 minutes, and requiring eardrums of pure steel - Enjoy!







Jack Bruce, Eric Clapton, & Ginger Baker

Here's a bonus Vimeo on Clapton's early technique




And an extra special bonus, after 37 years, Cream came back for a reunion series again at RAH! Here's Badge from May 3, 2005...



After the Cream breakup, Eric Clapton and some friends formed Derek and the Dominos. Here's a fantastic live track from Live at the Filmore: Let It Rain



Enjoy the birth of Hard Rock... Turn that volume UP!

The sad demise of Jack Bruce on Oct 25, 2014, a rock legend - http://en.wikipedia.org/wiki/Jack_Bruce

Listen watch and be amazed








Sunday, February 17, 2013

Trinket Snake Rescue


This tiny 18-inch-long Trinket snake (Coelognathus helena helena) was spotted three doors down from our place one evening. The team (Saranya, John Rommel and myself) were called into action by another neighbor, as the family that saw the snake promptly locked themselves in for safety! We grabbed our snake stick and a pillow cover and found the offender trying to climb the steps to the terrace. With a little gentle manipulation we got him on to the stick and then into the pillow cover.


Notice the threat display, s/he has a vertically flattened neck to appear truly dangerous, but though they do bite quite easily, these beauties are completely harmless, nonvenomous, and they will get used to handling after a short while. When really worked up, they will flatten the entire front third and fold up like an accordion. Now that, with a snake that can get to be 4 feet long can look truly terrifying!

The forest department declined to come over (that's the proper procedure) so we dropped our visitor off at the back end of a burial ground not too far away that's on the edge of a forested area with lots of thornbush scrub around. The happy snake swiftly slipped away to explore.


And Time Stands Still



Steve Gadd, Dave Weckl, Vinnie Colaiuta, 





Shot way back in 1989 at the Buddy Rich Memorial Concerts, these three incredible drummers got together for 9 unbelievable minutes, and time stood still - it still does!


Steve Gadd
 Dave Weckl



Vinnie Colaiuta







There was a moment when I was carried back to a village in Zambia near Mapanza. Invited to a wedding, a little boy stands amazed, the drums, the drums...

Thursday, February 14, 2013

A Violin Concerto!

Mendelsohn's Violin Concerto in E minor, opus 64, the 1st movement Allegro molto appassionato.

A bravura performance of the 1st movement by Julia Fischer


Enjoy 14 mins of blissful sound!

The other two movements of this piece are also on youtube :
2nd movement http://www.youtube.com/watch?v=lOd26lbPc8o
3rd movement http://www.youtube.com/watch?v=NswEr23Xuqo


and here's a pic of the violinist with her Guadagnini violin (1742)




Keep enjoying!

Tuesday, February 12, 2013

Cool Jazz, Brubeck's Piano & Sax in '66


The inimitable Dave Brubeck Quartet doing "Take Five"





Take Five is mainly a sax showcase (Paul Desmond) with the Brubeck touch seen only after 3 mins of scintillating sax. Enjoy!

Monday, February 11, 2013

Charles Dickens' Words of Advice to His Youngest Son


LETTER TO HIS YOUNGEST SON ON HIS DEPARTURE FOR AUSTRALIA IN 1868.[27]
My dearest Plorn,
I write this note to-day because your going away is much upon my mind, and because I want you to have a few parting words from me to think of now and then at quiet times. I need not tell you that I love you dearly, and am very, very sorry in my heart to part with you. But this life is half made up of partings, and these pains must be borne. It is my comfort and my sincere conviction that you are going to try the life for which you are best fitted. I think its freedom and wildness more suited to you than any experiment in a study or office would ever have been; and without that training, you could have followed no other suitable occupation.
What you have already wanted until now has been a set, steady, constant purpose. I therefore exhort you to persevere in a thorough determination to do whatever you have to do as well as you can do it. I was not so old as you are now when I first had to win my food, and do this out of this determination, and I have never slackened in it since.
Never take a mean advantage of anyone in any transaction, and never be hard upon people who are in your power. Try to do to others, as you would have them do to you, and do not be discouraged if they fail sometimes. It is much better for you that they should fail in obeying the greatest rule laid down by our Saviour, than that you should.
I put a New Testament among your books, for the very same reasons, and with the very same hopes that made me write an easy account of it for you, when you were a little child; because it is the best book that ever was or will be known in the world, and because it teaches you the best lessons by which any human creature who tries to be truthful and faithful to duty can possibly be guided. As your brothers have gone away, one by one, I have written to each such words as I am now writing to you, and have entreated them all to guide themselves by this book, putting aside the interpretations and inventions of men.
You will remember that you have never at home been wearied about religious observances or mere formalities. I have always been anxious not to weary my children with such things before they are old enough to form opinions respecting them. You will therefore understand the better that I now most solemnly impress upon you the truth and beauty of the Christian religion, as it came from Christ Himself, and the impossibility of your going far wrong if you humbly but heartily respect it.
Only one thing more on this head. The more we are in earnest as to feeling it, the less we are disposed to hold forth about it. Never abandon the wholesome practice of saying your own private prayers, night and morning. I have never abandoned it myself, and I know the comfort of it.
I hope you will always be able to say in after life, that you had a kind father. You cannot show your affection for him so well, or make him so happy, as by doing your duty.
Your affectionate Father.


Thanks to Brain Pickings (Maria Popova) http://buff.ly/WTfrJo

Friday, January 18, 2013

Rescue that Snake!

Rescuing snakes (from dangerous humans) is something that one does whenever the opportunity presents itself. One morning, I got a call saying there was a malaipambu (python) trapped in an agricultural well not far from where we live. The call came while I was out shopping, so I rushed home, handed over the groceries, picked up my snake stick and prepared to head out to the coconut grove where the well was. My son John Rommel and his friend Dinu both tagged along, and that was our team.

Along the way, my autodriver spread the word (as had the farmer), so when we got there, there were about 30 onlookers. I had my doubts about this operation because it was a well, and our Indian wells are rather rough things with typically precarious means of access. This well proved to be no exception, about 60 feet across and sporting a rugged and steep descent cut into two adjacent walls, with the water about 50 feet down.

Anyhow, we slowly worked our way down and soon saw that the supposed malaipambu was actually a large 6 foot (venomous) Russel's viper. The farmer had wanted to clean the well (it was a mess) and that's when the snake was spotted and misidentified, but luckily none of his workers were willing to face even a smallish nonpoisonous python, so we had been called in.

Now, ordinarily the Russel's is a dangerous snake to tackle and big ones even more so. They have powerful thick bodies, and can launch a strike to about 3/4 of their lengths and generally strike upwards, so people often get bitten at or above knee height. The Russel's is also known to strike with little or no provocation, in common with the saw scaled viper (and most unlike the other two of the 'big 4' the krait and the cobra). Now, while there is excellent antivenin available to deal with the bites of India's big 4 (see my post on this), A Russel's bite also causes extensive local tissue damage and awful ulceration, so surviving the bite is only one part of one's recovery!

We were very handicapped by the tight constraints of the 'steps' and by the fact that we could only just barely reach the water about 4 feet down from the final step. To our advantage was the fact that the snake was in water, cooled down, and therefore a bit more lethargic than otherwise.

S/He was swimming around the edges of the well trying to find some way out. Soon after we got down, s/he came round and I tried to get him on my stick but this proved impossible. There was a heavy rope lying at our feet, so my next attempt was with a loop of this rope let into the water.




I managed to get him about half way along his body with the loose noose, but when he was just below us he slipped back down.

After a few minutes he came back round and this time, using my snake stick, I guided him into the noose and then supported his back end with the stick. Rommel was ready with a heavy sack and into this we gently let him down. The top of the sack was tied and we triumphantly ascended with our beautiful Russel's viper.

We got home with our in-sack snake, only to find everyone in a bit of an uproar. We had guests at home (the Bonneys, all the way from Australia) Aruna's aunt and uncle, and they were all in a bit of shock, so the snake was photographed 'in-sack' and then left safely out of sight as we tried to contact the forest department to arrange for them to pick up our prize. That night the forest department staff came and picked him/her up and that was a successful rescue!

Learn to identify India's venomous snakes

Tuesday, January 01, 2013

Year 2013 AD

Here's wishing one and all a thrilling, wonderful, satisfying, and successful
2013 !!!

Sunday, December 30, 2012

I'm Terminal!

If you are terminally ill with one of the numerous diseases for which modern medicine seems to have no answers, or if you are involved in trying to find alternative treatments for someone in this position, then you will want to explore every possible treatment option - but can you, and can you do so ethically/legally?

The issues that arise are big and very important. A recent discussion at LinkedIn's Cell Therapy Industry Group examines some of these issues, and it got me thinking. The Nobel laureate Dr. Ralph Steinman blazed a lonely new trail, and one that is worth examining. There's an excellent writeup in the New York Times ("Is the Cure for Cancer Inside You?") on how Dr. Steinman courageously used his own pancreatic cancer to further explore his treatment options. I'd highly recommend that you read that article before delving into the issues raised on LinkedIn.

As it stands, a terminally ill patient will have a very difficult time emulating Dr. Steinman's example. The regulations in most countries, and especially in the US, simply forbid an extremely individual approach to treatment. There are the standard, tested courses of treatment available to all, but stepping outside of approved treatment protocols & regimens is mostly prosecutable, could well result in a physician losing her license, and probably stiff monetary consequences.

But that leaves the terminally ill patient in a very unenviable position, for it is also acknowledged that following these "standard, approved", treatment options will result in fairly certain and fairly quick mortality. In other words, it's because the treatments are failures that patients are thought of as 'terminal'. Technically, it is possible for a patient in consultation with his physician to try to get approval for an experimental treatment, but that is a lengthy and laborious process (perhaps by design), and when time is of the essence...

What many patients opt for instead, is to enroll themselves in one of the many clinical trials revolving around their particular illness. Again, not a terribly exciting option, for there's a very big chance that you will end up as a 'control' and receive a placebo perhaps with the nonfunctional standard treatment. Even if the particular experimental treatment works for some of the patients in the trial, that might not be you. Even if it worked well in the trial, there's then no telling how long it will take for it to come through the regulatory processes and become an available option for you. One is left with the dubiously satisfying notion that by participating, one has perhaps pushed the cause of science a little further, and very likely at the cost of one's own life!

When we think of what Dr. Steinman achieved, he can be seen to have blazed a trail through the impenetrable jungle of federal regulation. His drive, focus, and stubbornness speak volumes and he achieved the near impossible. We are amazed, for even though he was in a unique position, able to direct his own well-funded research, and to request, and get, an incredible degree of cooperation from eminent specialist researchers from all over the world, he not only  got away with it, he indeed seems to have succeeded in prolonging his own life well beyond the norm for the kind of disease that he was suffering from. His example is both inspiring and inspires despair in those who have not his level of influence and are not researchers in their own right.

And this brings up the question of ways and means. In short, at present there are none. The regulations are stultifying. Some of the very rich may be able force their way to their own experimental treatment (one thinks of a Steve Jobs), but for all the rest there are neither the funds, nor acceptable methodologies. Funds would probably be available if there was a clear path to commercialization, but when we are talking about individualizing therapy for the many millions who may be considered 'terminal' it is precisely the lack of any business model that is a big problem. One could go further, for if our cures are primarily found within ourselves, the days of 'big pharma' are probably numbered anyway.

Ideally of course, wherever business fears to tread should precisely be where the government steps in. Unfortunately, the whole picture of drug/treatment approvals has been hopelessly skewed to cater to the major business interests, and the entire regulatory mechanism simply sidesteps the needs of the hopelessly uncommercial 'terminally ill.' The poor patient, and that could be you or I too, just down the road - are left to the tender mercies of the licensed to kill 'standard, approved' treatment options!

The regulators are not just being stubborn. From the standpoint of regulating authorities like the FDA, one problem is accountability, as they are ultimately responsible for each life lost in a medical setting. A failed, poorly tested, poorly understood experimental treatment attempt, even when wholeheartedly entered into by a patient-physician combo, does not let them off the hook. It's also easy to see that the terminally ill patient population is particularly susceptible to quackery. Any hint of hope offered, can become irresistible, and can very easily be a conduit for parting the desperate patient from whatever funds they may have or be able to raise. Folks do need protection against such quacks.

What really is a federal regulatory authority's main purpose? An FDA is first and foremost tasked with safeguarding the health of an entire population of many millions - and that is what they are structured to do. They are simply not in a position to handle individual requests for individual therapies. The very nature of the highly individual immunology-physiology of most intractable diseases, the genetic variations that affect outcomes, and the immense number of potential treatments that could be opted for, means that blunt regulatory tools that work well for protecting large populations are completely (woefully) inadequate at an individual level.

I think it's possible to closely regulate the workup and counseling of patients with terminal illnesses, and still allow the patient and their physician to be the deciders on how to best proceed and with which particular treatment, however experimental. After ensuring a complete History and Physical is taken, and all previous medical records are on file, the data to be gathered and generated during the treatment can be rigorously specified so that each patient's progress can be carefully monitored while a meaningful database is developed which can be openly accessed and studied by researchers.

What it should boil down to, is that apart from setting some overall boundaries and demanding rigorous clinical records to be maintained, the regulatory authorities can safely stay out of fiddling with an approval process for each individual case. Certainly counseling can be required, both in the beginning and at regular intervals during the process of treatment.

Where does big pharma fit itself into this picture? Well, here is a troubling problem. For one thing, the present process by which drugs gain approval is heavily tilted towards a big pharma R&D to clinical trials scenario. Eventually, a drug that has gone through this process will be released for use by a huge medical community, and big pharma gets to recoup their costs and then make a healthy profit.

In spite of this, big pharma could well participate at an individual level and even help with providing funding and/or material support in the form of therapies under development. Unfortunately, and understandably too, most companies are leery of allowing their drugs under development to be used in situations that might just earn the drug a bad name while it is still in the midst of an involved and costly approval process. Any false step may well kill off a promising drug candidate early. Some creative thought on a thorny issue is warranted. The facilities available to big pharma for developing individualized therapies are unparalleled, but without a payoff, these will remain unutilized.

The combination of millions of cancer subtypes, evolving cancers, and the individuals' own incredible variability, is mind boggling. The same is true of other common terminal illnesses like multiple sclerosis. So many irreversibly progressive illnesses have strongly individual characters and require individually tuned therapies. One person's illness, even when apparently classified and staged in common with other 'similar' patients, can still have a stubbornly unique progression. It's only natural then that the treatment too has to be individually designed.

Clinical trials, as now commonly set up, are geared to large numbers where individual responses are unimportant. Results instead have to attain statistical significance when compared with the placebo groups (effectively the untreated 'control') in order to count for anything. Of course, with the advent of big data, as well as the deeper analysis of results, we are increasingly seeing subgroups and subtypes identified, and there is now more appreciation of individual responses. When a system is designed to test overall statistical trends, it's not surprising to note that it has resulted in a regulatory framework that's almost impossible to adapt to an individual's needs. The system has fed off itself and spiraled into an inflexible megalith. The system is also what 'big pharma' is happy with and is very happy to maintain the status quo.

I have only touched on some of the very many issues surrounding this discussion. It should be obvious that new ways of funding individual therapies need to be worked out. Only a tiny proportion of people will be able to work on their own disease as effectively as Dr. Steinman could. He had at his disposal a large, well funded research establishment, and there will be none who are similarly blessed. Again, I think creative solutions may occur to those both in and outside of 'big pharma' who may see an opportunity to bridge their own transitions through the upcoming changes in how medicine is to be done. It follows that it will behoove the insurance sector to follow suit!


Dr. Steinman has shown us the tremendous potential of allowing the terminally ill patient to explore individually tailored therapy. If we properly organize and carefully gather the data that results and then study it properly, it will eventually prove a broad and useful base for increasingly meaningful 'terminal' decision making. What looks from a scientific standpoint to be hugely messy, may eventually prove to be the path to a new way of doing medicine, not only for the terminally ill, but for every patient, and indeed for every single individual.

In one (critically important) sense we are all terminal, we just don't generally choose to face our own mortality in such stark terms.


You may also want to look at these updates:
 
1. Autologous cell therapies: challenges in US FDA regulation:
https://www.box.com/s/waxwfciz1eqxsbinvmxu?goback=.gde_135553_member_195931915 
Discusses why autologous cell based therapies (i.e. stem cells from our own bodies) are yet to make the kind of impact expected of them. Again the FDA is the main culprit. Read it for yourself...

Stem Cell Showdown: Celltex vs. the FDA http://www.businessweek.com/articles/2013-01-03/stem-cell-showdown-celltex-vs-dot-the-fda

The Truly Staggering Cost Of Inventing New Drugs:  http://www.forbes.com/sites/matthewherper/2012/02/10/the-truly-staggering-cost-of-inventing-new-drugs/?goback=.gde_3363923_member_199828696

Regenerative Medicine: Engineering Its Continued Success: Geoff Mackay, http://genengnews.com/bioperspectives/regenerative-medicine-engineering-its-continued-success/4653

Cell-Based Therapies for Malignant Brain Tumors by Nousha Khosh on Tue, Jan 15, 2013 http://info.sanguinebio.com/neurology/bid/202701/?utm_campaign=Researcher-Facing&utm_source=linkedin&utm_medium=social&utm_content=00e7420a-411f-4b74-b7b0-3eccc98279a3

FDA Challenges Stem Cell Companies As Patients Run Out Of Time NPR http://www.npr.org/2013/02/02/170942324/fda-challenges-stem-cell-companies-as-patients-run-out-of-time 

update on Feb 28, 2013

See the Patients for Stem Cells site and their research into the safety of stem cells for treatment : Patients for Stem Cells http://www.patientsforstemcells.org/  update March 13, 2013

If you are a LinkedIn member, check out this fascinating discussion that nails all the facts to date: http://linkd.in/15MkmPf

3. There's a big battle on right now in Europe, where an exemption clause allows some individuals to get stem cell treatment on a case by case basis if a hospital will allow it. One case in point is in Italy where Recently the Italian health minister, Renato Balduzzi, has decreed that a controversial stem-cell treatment can continue in 32 terminally ill patients, mostly children — even though the stem cells involved are not manufactured according to Italy’s legal safety standards.The unexpected decision on 21 March (2013) has horrified scientists, who consider the treatment to be dangerous because it has never been rigorously tested. http://bit.ly/XqfAqw  

Now, an article in EMBO warns of dire consequences if the usual route of clinical trials etc. is bypassed in Italy and they draw the very odd analogy of BMT (bone marrow transplant)! The EMBO article is available in full and EMBO also did a short summary of it. Now, this is timed to affect the debate in the Italian parliament that threatens to legalize the use of autologous stem cell therapies and leaves the decisions in the hands of the patients and their physicians when the disease that they are attempting to treat is terminal. I'll keep the readers posted on where that ends up!

4. The Other Side of the Stem Cell Coin! Over regulation etc.

The famous journal Nature and the US FDA have been arguing that unauthorized stem cell treatments are potentially very dangerous, that the science is not simple, in fact is very complicated, and therefore is fraught with risks of everything from tumors to immunological complications. I refer you to what is generally available after googling the issue:

The darker side of stem cells (editorial) Nature 483, 5 (01 March 2012) doi:10.1038/483005a Published online Ensuring Safety and Efficacy of Stem Cell-based Products Principal Investigator: Steven R. Bauer, PhD.  Office / Division / Lab: OCTGT / DCGT / CTTB seen March 14, 2013

There are two major problems with the FDA's approach. First, if a patient asks what stem cell based "approved treatment" options exists, the answer now is essentially  nada NONE. Second, it is very unclear indeed as to what the process is like to become an approved stem cell treatment center.  Beyond these basic flaws (which are rather fatal to the FDA's claims), it also looks like the FDA is itself trying to do the basic research on stem cells, bypassing the whole of the established research community, and this means that whatever they are going to DO eventually will take an unforgivably long time. I am not an expert on any of these matters. I do hope (as a blood banker), that the incredible infrastructure that exists in blood/tissue banks can be put to even greater use by including stem cell processing/storage as a routine. All that would require is for the cGMP and acceptable protocols to be published by the FDA. However, that hope is very faint at this point! Technically, all the 'issues' like needing safe, sterile closed systems, can be easily overcome!

Here's an article in the Monday, October 3, 2011 WSJ by Dr. Scott Gottlieb a former Deputy Commissioner of the USFDA : How the FDA Could Cost You Your Life that well illustrates some of the startling problems faced from over regulation by the USFDA.

And now this - a 10-year old girl who desperately needs an adult lung transplant is ruled inadmissible 'too young' by the US FDA Watch it here - http://video.foxnews.com/v/2431370334001/parents-race-to-save-sarahs-life and it took a judge's order to get her the transplant. The parents pleas to the FDA fell on deaf ears

The Harvard Law Blog "Bill of Health" has thrown in their two bits here http://hvrd.me/1847wR3 Our Bodies, Our Cells: FDA Regulation of Autologous Adult Stem Cell Therapies Posted on by Katharine Van Tassel By Mary Ann Chirba, J.D., D.Sc., M.P.H. and Alice A. Noble, J.D., M.P.H.


5. On the commercial problems faced by autologous stem cell therapies, here's a decent writeup-analysis of the difficulties faced by one of the SCSI's members Aastrom http://bit.ly/Zy3SYk

6. The fight for the genome. If human genes can be patented, a huge revolution in medicine will die a quick death. The fight is on now. Here's a brief rundown by PBS Nova: Are Gene Patents Standing in the Way of Personalized Medicine?

http://www.pbs.org/wgbh/nova/next/body/gene-patents-and-personalized-medicine/  

7. Find out more about a model for making stem cell therapies clinically realistic :"For the past four years I have been following the work of the ‘Blood Pharma Project’, which is seeking to culture red blood cells in the laboratory from pluripotent stem cells, with the eventual aim of creating a clean and unlimited source of red blood cells for transfusion." Emma King - http://www.eurostemcell.org/commentanalysis/making-red-blood-cells-model-stem-cell-therapy-development 

Please do let me know of any advances/changes as they occur by posting comments below, so that we can together try to keep the information current and useful.

 

Wednesday, December 26, 2012

Money, Happiness & Giving, is there a link?


Full of good stuff, this short & sweet video lays it on the line



Money can bring you happiness but not by buying... do you agree? Either way, comments are welcome.


Tuesday, December 25, 2012

Survival of the Fittest

Getting into the jungle in any part of the world can be thrilling, whether one sees any big game or not! But sometimes some folks get extra lucky, and just sometimes they're so lucky that they get some good pics or, as in this case, an incredible video. Shot at the Kruger National Park in South Africa, this one's a safari classic featuring a battle over a buffalo calf who is first captured by a pride of lions, and then along come the crocodiles... Watch to see what happens next!



Nature seems so cruel, yet the lions, and the crocs too, have to eat to stay alive. Predators at the top of a huge food pyramid serve nature by weeding out the weak and the unfit. This in turn trims the gene pool, rather clumsily at times, but in the long run it all works out, and sometimes even in ways that humans can applaud!

Thursday, September 13, 2012

Blood Bankers Ahoy!

There's a new discussion group on LinkedIn that I am inviting you to join. It's the Blood Components group, an open group for blood bankers and anyone interested in blood components, to join, comment, discuss, and share. The supporting blog called (rather unsurprisingly) Blood Components, can also be visited and supporting documentation etc will be hosted there.

Welcome one and all!

Two other posts on my personal blog (Challenge) that you might find interesting are:

Blood in Times of Scarcity http://bit.ly/SlxPnY Discusses various techniques for getting around blood shortages and some tricky situations when blood may be in demand but not available. It was prompted by the Pakistan platelet crisis but also discusses a wide range of common blood crisis scenarios.

Platelets in Developing Countries http://bit.ly/Slyfur Was a post I did at the time of the last (2011) dengue crisis in Pakistan and has general thoughts on how to (and how not to) deal with a sudden demand for platelets.

Most voluntary blood donors just go out and donate their blood, assuming that it will reach a needy patient. In the developed world, mostly your blood will then go on to save 3 or more lives, because your blood will be routinely processed into its component parts, red blood cells, platelets, and plasma, and each of these is needed to save the lives of those who are short of that particular component.

Unfortunately, in many parts of the developing world, because of cost and infrastructure shortages, blood donated as whole blood often gets issued to patients as whole blood, and that's both bad for the patients and terribly wasteful. The blood components initiative tries to tackle these issues, increasing awareness, and tackling any technical issues that may arise. Join us! 


Thursday, August 02, 2012

Ugh! Facebook and their New TL

The Facebook phenomenon has been a hallmark of the 3rd millennium's internet. Along with Google, Wikipedia, and perhaps now Twitter, these net tools are considered fundamental, even essential. They have stood the test of time, proved to be of tremendous utility, made the leap to mobiles, tablets, n pads, and have just kept growing, and seem to become ever more entrenched, tweak after tweak.


But the internet is a strange space, fickle, fey, and dangerous to the unwary. Many millions of inventions and innovations have come, and just as quickly been swallowed by the abyss. Success is rare and never sits comfortably nor with certainty.


I therefore was very recently surprised to open my Fb, click on my name at the top right (as usual)  and found a strange new thing. The profile page had changed, it was now unrecognizable, it was startling, and confusing. I mean, seriously, Fb expects me to zig-zag my down their page!


Looking once more, at the top was a box that said:
"Welcome to Your Timeline — Preview"


Now, I did know that Fb had rolled out this thing quite a long time ago. I had even looked at this new timeline (TL) thing on a friend's page and decided then that it was just not for me.


I had googled it then, and found that Fb 'promised' that it was optional. Those that wanted to could supposedly just keep the old look. I then fastidiously ignored the thing  despite many offers from Fb (at frequent intervals) to "try it out." 


Now, Fb has a funny way of using words. Their versions of "like" or "friend" are only one small example. Many folks along the way told me that they had 'tried' the new TL and then found that it was stuck in permanently. So, the Fb "try" =  = irrevocable. This made me even more careful, and I had avoided clicking anything anywhere near these temptingly phrased 'trial' offers.

Suddenly seeing this strange and garbled TL thing on 'my' page really irritated me. I read through the info box carefully and it was obvious that (as usual with Fb), there was no choice being offered. It was a "take it in 3 days, or take it now" offer.

I did all the usual things, lodged a complaint, sent in an email, protested on the home page itself, and then, when met with utter silence from Fb, I finally googled for a "Facebook timeline solution". 

Lo and behold, google had 86,000,000 YES millions of hits on that! Page after page after page, of proposed solutions.

Well, it was immediately heartening to see that I was not the only miffed-at-Fb person on the planet. It was also nice to see that there did seem to be such solutions as:
1,  http://www.timelineremove.com/
2, http://www.fbpurity.com/remove-facebook-timeline.htm
and 
3 http://www.youtube.com/watch?v=_3Ib4cdV6kk


Solutions were apparently available for a number of browsers; Chrome, Firefox, Safari, Opera etc. excepting apparently IE as of now. Now, if there is enough demand for a change that apps are being created and deployed to solve the TL issue, the problem for Fb is not just a minor hiccup - it is big, perhaps even huge.


I then decided to do a bit of digging. Why on earth was Fb insisting on rolling out a change that seems to have been so universally hated? It is a distinctly odd thing for any business to do. Why not just leave well enough alone? A juicy question isn't it? So, I started doing a bit of research. No one seems to really know WHY. There is a lot of speculation though.


Here are some of the main possible Fb newTL motivations that I came up with:
1) Market research perhaps initially indicated that the new TL really is great and will make Fb even more addicting once it gets accepted, and that acceptance should follow after a minimal initial resistance.


2) The new layout offers a much greater potential for ads and ad responsiveness - which is bread & butter after all - so it HAS TO be implemented. Even a 10% loss of subscribers will be more than offset by a 50% or greater growth in promo income.


3) Zuckerberg-Fb & Co. just love their discovery so much, have put so much heart into it, and are so committed to the TL idea (that people should want to have their whole lives zig-zagging down one Fb page) that they are shoving it down everyone's throat, opinion be damned, even if some of the lemmings wake up - and even if they lose some business too.


Facebook Inc. having recently gone for a public share issue with the subsequent hugely hyped stock roll out have, I think, brought matters to a head.  The share prices have been steadily tumbling. Share prices are dependent on earnings, and the first reported results were not very encouraging. Probably, something drastic is needed on the earnings front - that means more ad revenue - that perhaps means the new TL. 


Incidentally, I did notice that in it's new avatar, my profile page actually sports very few ads, and that really is suspicious! The revenue, and flood of ads, therefore awaits the full TL roll-out...


But, there is at least one other possibility. Perhaps there is a move on to drive the share prices down.  First report equivocal earnings, then allow the TL issue to be an irritant, but do lay the foundation for much increased revenues in the future. This suspicion is reinforced by the fact that the shares given to employees are nearing the end of their lock-in periods and will shortly flood the market, especially if these folks feel that the price might be going to head south very shortly.  Large blocks of shares can then be picked up at throwaway prices. 
Or perhaps I'm just an overly suspicious sort...


Either way, the new TL experience has been fascinating. I may even renege on quitting (Fb altogether) if one of the solutions above actually continues to work. 


But one thing is sure, Fb's only concern is to make the big bucks (even bigger BIG bucks), as any well run corporation should do, and no amount of temporary angst matters at all. Neither are they overly concerned about long-term heritage issues. 


The overall feeling that one gets from Fb about the loyalty of followers, is that when Fb gives each one such a fantastic, ego-stroking, feelgood experience, the followers will remain in line. After all, one can't get anything this addicting anywhere else, and FOR FREE. 


No kidding at all - the addiction potential is so great that it is, for many, life destroying. And that's of course what also makes it addicting to advertisers - the bottom line.


If that isn't a win-win situation, what is?



SHARE THIS NOW

Google+ javascript:(function(){var now=new Date(),month=now.getMonth()+1;day=now.getDate();year=now.getFullYear();window.polarbear=window.polarbear||{};var D=550,A=450,C=screen.height,B=screen.width,H=Math.round((B/2)-(D/2)),G=0,F=document,E;if(C>A){G=Math.round((C/2)-(A/2))}window.polarbear.shareWin=window.open('https://www.polarbearapp.com/app','','left='+H+',top='+G+',width='+D+',height='+A+',personalbar=0,toolbar=0,scrollbars=1,resizable=1');E=F.createElement('script');E.src='//www.polarbearapp.com/js/web-bookmarklet.js?v='+month+'-'+day+'-'+year;F.getElementsByTagName('head')[0].appendChild(E)}());